Wayne O'Brien played college ball at St. Mary's and McMaster before being drafted in the second round of the 1968 CFL college draft by the Hamilton Tiger-Cats. O'Brien played one season in the CFL with Montreal in 1969.
| Year | Team | GP | Int | Yds | Avg | TDInt | Long | FR | Yds | Avg | TD | Long | FF |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1968 | MON | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 |
| Year | Team | KOR | Yds | Avg | TD | Long |
|---|---|---|---|---|---|---|
| 1968 | MON | 1 | 5 | 5 | 0 | 5 |
