Matt Dunigan signed with Edmonton in January, 1983. He saw limited action in his rookie season as he was the backup to Warren Moon , but he did throw 4 touchdowns in only 26 attempts. Dunigan moved into the starter's role in 1984 when Moon went to the NFL and was one of the best running QBs in he CFL, as he racked up 732 yards in 1984 and 737 yards in 1985 which at the time was a CFL record for yards rushing by a QB. HIs feet, along with a 59.6% completion percentage in 1985, earned Dunnigan his first All Canadian recognition. Dunigan soet five years with Edmonton (1983-87) and Edmonton went to the Grey cup in both 1986 and 1987, winning in 1987. Dunigan, however, spent most tof the Grey Cup on the bench due to an injury while Damon Allen filled in at quarterback. Dunigan was traded to BC in a big deal for WR Jim Sandusky and future considerations. The future considerations turned out to be LB Jeff BraswellLB Greg Stumon, RB Reggie Taylor, DB Andre Francis, DE Leroy Blugh and BC's first round pick in the 1989 college draft. Dunnigan played two years in BC (1988 and 1989), earning his second All Canadian honour in 1988 though his stats in 1989 were better as he hit career highs in passing yards with 4509 and touchdown passes with 27.
Dunigan was traded to Toronto after the 1989 season for QB Rick Johnson, LB Willie Pless, LB Tony Visco, WR Emanual Tolbert, DB Todd Wiseman and DT Jearld Bayliss. Dunigan played two seasons in Toronto (1990-91), but injuries limited him to
only 8 games in each of those two seasons. Dunigan did, however, win a Grey Cup with the ARgos in 1991. That was the year the Argos went 'Hollywood" with the purchase of the team by actor John Candy, Wayne Gretzky and Bruce McNall who owned the LA Kings. Dunigan was injured in the East final, but injections to kill the pain, played in the Grey Cup and threw a pair of touchdown passes.
Dunigan became a free agent and signed with Winnipeg in June, 1992. His first year in Winnipeg, was Dunnigans worst statistically in his career with a 49.9% completion perecentage, but he followed that with maybe his best year in his career in 1993. In 1993, Dunigan threw for 4682 yards and 36 touchdowns as was named an East All-Star and was the runner-up for the Most Outstanding Player award. Dunnigan followed up in 1994 with another Eastern All-Star selection as he threw for 3965 yards in only 11 games. Dunigan went to the Grey Cup in both 92 and 93 with the Bombers, losing in 92 and winning in 93, but Dunigan had to watch the game on crutches due to an injury.
Dunigan became a free agent prior to the 1995 season and signed with the expansion Birmingham Barracudas. Birmingham was a pass crazy team and Dunigan set career highs in passes thrown (642), passes completed (352) and yards (4911) and was just short in TDs with 34. Those kind of stats earned Dunigan his third All Canadian selection. With the folding of the US based teams, Dunigan became a gree agent again and signed with Hamilton for 1996, his last season in the CFL.
In 2006, Dunigan was named #39 in a TSN poll of the top 50 players in modern CFL history. He was also elected to the Canadian Football Hall of Fame.
After his retirement, Dunigan moved into the broadcast booth on TSN and had a brief one year stint coaching the Calgary Stampeders before returning to TSN.